Table 3.
Univariate and Multivariate Analysis of Prognostic Factors in the Training set, Testing set and Meta-validation Set.
| Data sets | Variables | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | ||
| TCGA-training | Age | 1.04 (1.02–1.06) | 1.76e-04 | 1.04 (1.02–1.06) | 2.98e-04 |
| Stage | 1.33 (1.17–1.52) | 1.69e-05 | 1.25 (1.10–1.43) | 7.68e-04 | |
| PAM50 subtype | |||||
| LumA/LumB | Reference | Reference | |||
| HER2-enriched | 1.90 (0.99-3.70) | 0.055 | – | – | |
| Basal-like | 0.83 (0.45–1.55) | 0.56 | – | – | |
| IRGPI | 2.72 (2.09–3.54) | 7.99e-14 | 2.51 (1.92–3.27) | 1.08e-11 | |
| TCGA-testing | Age | 1.03 (1.00–1.06) | 0.028 | 1.03 (1.01–1.06) | 0.012 |
| Stage | 1.38 (1.07–1.78) | 0.012 | 1.37 (1.05–1.78) | 0.019 | |
| PAM50 subtype | |||||
| LumA/LumB | Reference | Reference | |||
| HER2-enriched | 0.97 (0.28–3.29) | 0.96 | – | – | |
| Basal-like | 0.72 (0.24–2.12) | 0.55 | – | – | |
| IRGPI | 2.34 (1.48–3.70) | 2.6e-04 | 2.16 (1.34–3.49) | 0.0015 | |
| Meta-validation | Age | – | – | – | – |
| Stage | – | – | – | – | |
| PAM50 subtype | |||||
| LumA/LumB | Reference | Reference | |||
| HER2-enriched | 2.33 (1.59–3.42) | 1.41e-05 | 2.48 (1.69–3.65) | 3.53e-06 | |
| Basal-like | 1.45 (0.91–2.33) | 0.12 | – | – | |
| IRGPI | 1.14 (1.04–1.76) | 0.001 | 1.69 (1.2–2.39) | 0.0028 | |
Bolded values represent significant shifts in plausibility (P value < 0.05).