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. 2020 Jan 28;10:1622. doi: 10.3389/fphar.2019.01622

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Copyright © 2020 Chen, Ji, Zheng, Yang, Ren, Li, Han, Zhou, Liu and Qiu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pretreatment with PPAR-α antagonist MK886 blocked the effects of PEA on SD-induced mice LG. MK886 blocked tear production (A), normalization of LG (B) and acinar cell size (C) rescued by PEA in SD-induced mice. Transmission electron microscope (TEM) observation indicated that the effects of PEA against lipid accumulation, mitochondrial swelling, and nuclear pyknosis were completely abolished by pretreatment of MK886 (D–F). **, P < 0.01, ***, P < 0.001 vs. control group; ns, not significant, ^##, P < 0.01 vs. vehicle group; ^§§, P < 0.01 vs. PEA group; one-way ANOVA followed by Dunette’s post hoc, n = 5.