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. 2020 Jan 28;10:1622. doi: 10.3389/fphar.2019.01622

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Copyright © 2020 Chen, Ji, Zheng, Yang, Ren, Li, Han, Zhou, Liu and Qiu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PEA normalized the ultrastructural features of LG. Representative transmission electron micrographs of normal acinar cell (A scale bars: 10 μm) and endoplasmic reticulum (ER, B, scale bars: 1 μm). SD induced secretory granules fusion (C, red arrows, scale bars: 5 μm), dilated cisternae of the ER (D, red arrows, scale bars: 5 μm), nuclear pyknosis (E, scale bars: 1 μm), and swollen mitochondria (F, scale bars: 200 nm) in LG acinar cell. PEA treatment restored the normal morphology secretory granules, ER (D, green arrows), nuclear and mitochondria. n = 3.