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. 2020 Jan 28;10:1622. doi: 10.3389/fphar.2019.01622

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Copyright © 2020 Chen, Ji, Zheng, Yang, Ren, Li, Han, Zhou, Liu and Qiu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PEA increased conjunctival goblet cells number and tear secretion. Representative images of PAS conjunctivae staining (A), scale bars: 150 μm. Goblet cell density (B) and tear production (C) were expressed as mean ± SD in non-treatment control group (Ctrl), sleep deprivation (SD) for 10d group (10d), SD for 10d + solvent vehicle group (Veh), and SD for 10d + 30 mg/kg PEA treatment group (PEA). ***, P < 0.001 vs. control group; ^##, P < 0.01 vs. vehicle group, one-way ANOVA followed by Dunette’s post hoc, n = 5.