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. 2020 Jan 28;11:52. doi: 10.3389/fimmu.2020.00052

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Copyright © 2020 Knipper, Wright, Cope, Malissen and Zamoyska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTPN22 controls T cell proliferation when IL-7 availability is limited. (A) Scheme of experimental set-up. (B) CD4 and CD8 T cell frequency in blood 3 and 10 days post T cell depletion in combination with IL-7Rα blockade. Data means with SD shown, N = 7 animals per genotype and time point. Two-way ANOVA with Sidak's multiple comparison test. (C) Analysis of T cells number and IFNγ expression in spleen 2 weeks post T cell depletion or T cell depletion in combination with IL-7 Rα blockade. Each dot represents one animal, N = 7–8 animals per group, shown data is pooled of two independent experiments. Two-way ANOVA with Sidak's multiple comparison test. A p < 0.05 was considered significant ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001.