Table 1.
List of CircRNAs involved in treatment resistance in human cancers.
| Type of cancer | Sequence name | Expression | Intersection molecules and/pathway | Sample type | Resistant to (chemotherapy/radiotherapy) | References |
|---|---|---|---|---|---|---|
| Esophageal squamous cell cancer | circRNA_000167 circRNA_001059 |
Down | Wnt/β signaling pathway | Cell line | Radioresistant | (Su et al., 2016) |
| Colorectal cancer | circFAT1 circARHGAP5 |
Down | EGFR/MEK/ERK signaling pathway | Cell line | Chemoradioresistant | (Dou et al., 2016) |
| ciRS-7 | Up | miR-7/EGFR/RAF1/MAPK | Tissue | Chemoresistant | (Weng et al., 2017) | |
| hsa_circ_0000504 | Up | miR-485-5p/AKT pathway/STAT3 | Cell line | Chemoresistant (5-Fluorouracil drug) | (Xiong et al., 2017) | |
| Lung adenocarcinoma | CCDC66 | Up | HGF/c-Met pathway and MAPK | Tissue and cell line | Chemoresistant (Gefitinib drug) | (Weng et al., 2017) |
| Leukemia | f-circM9 | Up | PI3K/AKT1 | Cell line and xenograft model | Chemoresistant (Ara-C drug and arsenic oxide) | (Lehmann et al., 2001) |
| Osteosarcoma | circPVT1 | Up | Drug transporter pathway ABCB1 gene |
Tissue | Chemoresistant (Doxorubicin,cisplastin drug) | (Zeng et al., 2018) |
| Pancreatic cancer | chr14:101402109-101464448+ and chr4:52729603-52780244+ | Up | mir-145-5p/ErbB and VEGF | Tissue and cell line | Chemoresistant (Gemcitabine drug) | (Shao et al., 2018) |
| Breast cancer | Circ_0006528 | Up | miR-7-5p/MAPK and PI3K signaling pathway | Tissue and cell line | Chemoresistant (Doxorubicin drug) | (Nanba and Toyooka, 2008; Miao et al., 2017) |
| Non-small cell lung cancer (NSCLC | hsa_circ_0004015 | Up | miR-1183/PDPK1/Akt-mTOR pathway | Tissue and cell line | Chemoresistant (EGFR-TKIs drug) | (Zhou et al., 2019) |
| Gastric cancer | circRNA AKT3 | Up | miR-198/PI3K/AKT | Tissue and cell line | Chemoresistant (cisplatin drug) | (Huang et al., 2019) |
| Thyroid cancer | circRNA EIF6 | Up | miR-144-3p/TGF-α/PI3K/AKT | Tissue and cell line | Chemoresistant (cisplatin drug) | (Liu et al., 2018) |
| Temporal lobe epilepsy | circRNA 0067835 | Up | miR-155/FOXO3a/PI3K/AKT | Tissue and cell line | Antiepileptic drugs (AEDs) | (Guo et al., 2018) |
| Bladder cancer | circELP3 | Up | ELP3/HIF)-1 | Tissue and cell line | Chemoresistant (cisplatin drug) | (Su et al., 2019) |