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. 2020 Jan 28;10:1646. doi: 10.3389/fphar.2019.01646

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Copyright © 2020 Bai, Sun, Pan, Yang, Li, Wu, Qin, Cao, Zou and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibitory effect of TMEA on the growth and migration of HUVECs. (A) The proliferation rate of HUVECs were determined by the MTS assay; (B) The migration pattern of HUVECs after treatment of various concentrations of TMEA (3, 15, 30, and 60 μM) or sorafenib (10 μM) at 0 and 24 h under a phase-contrast microscopy; (C) Summary bar graph of the effect of TMEA and sorafenib on migration of HUVECs treated with TMEA or sorafenib for 24 h. (D) Effect of TMEA and sorafenib on tube formation of HUVECs. The data are presented from at least three independent experiments run in triplicate and expressed as mean ± SD. *p < 0.05, **p < 0.01 compared with the vehicle-treated controls by one-way univariate analysis of variance (ANOVA). TMEA, 3,3',4'-trimethylellagic acid.