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. 2020 Jan 28;10:1646. doi: 10.3389/fphar.2019.01646

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Copyright © 2020 Bai, Sun, Pan, Yang, Li, Wu, Qin, Cao, Zou and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relative expression of the related mRNA of Bax (A), Bcl-2 (B), caspase-3 (C), in SW620 cells and VEGF (D), PI3K (E), and mTOR (F) in HUVECs. The cells were treated with various concentrations of TMEA (3, 15, 30, and 60 μM) or sorafenib (10 μM) for 12 h. The data are presented from at least three independent experiments run in triplicate and expressed as mean ± SD. *p < 0.05, **p < 0.01, compared with the vehicle-treated controls by one-way univariate analysis of variance (ANOVA). PI3K, phosphoinositide 3-kinase.