Table 3.
Gene ontology (GO) analysis of 36 target genes of miRNA-195 (list by PValue).
| Type | Term | Count | PValue | Genes |
|---|---|---|---|---|
| Molecular Function | protein binding | 30 | 0.000145982 | KIF23, CLSPN, E2F7, CBX2, CHEK1, CEP55, AMOTL1, VCL, CCNE1, RAB23, FASN, TMEM100, MYB, SIK1, FGF2, CDCA4, AKT3, RECK, PTPRD, RUNX1T1, CDC25A, ITPR1, WEE1, BTG2, SALL1, TGFBR3, LSM11, KATNAL1, WNT7A, ALOX12 |
| Biological Process | regulation of cell cycle | 4 | 0.002164798 | CCNE1, FGF2, CDC25A, WEE1 |
| Biological Process | Positive regulation of endothelial cell migration | 3 | 0.004123996 | WNT7A, FGF2, ALOX12 |
| Biological Process | somatic stem cell population maintenance | 3 | 0.008085217 | SALL1, WNT7A, FGF2 |
| Biological Process | stem cell development | 2 | 0.012442813 | WNT7A, FGF2 |
| Cellular Component | nucleoplasm | 12 | 0.012459971 | KIF23, CLSPN, CCNE1, E2F7, SALL1, RUNX1T1, LSM11, CHEK1, CBX2, AKT3, CDC25A, WEE1 |
| Biological Process | positive regulation of transcription, DNA-templated | 5 | 0.021591723 | CCNE1, SALL1, MYB, WNT7A, FGF2 |
| Biological Process | positive regulation of endothelial cell differentiation | 2 | 0.022696818 | TMEM100, ALOX12 |
| Cellular Component | nucleus | 17 | 0.032803617 | KIF23, CPEB2, E2F7, CHEK1, CBX2, WEE1, CDC25A, CCNE1, ZFHX4, SALL1, LSM11, MKX, SIK1, MYB, KATNAL1, FGF2, CDCA4 |
| Biological Process | G2/M transition of mitotic cell cycle | 3 | 0.032988025 | CHEK1, CDC25A, WEE1 |
| Biological Process | cell division | 4 | 0.035939287 | CCNE1, CDC25A, CDCA4, WEE1 |
| Biological Process | positive regulation of blood vessel endothelial cell migration | 2 | 0.038888456 | AMOTL1, FGF2 |
| Cellular Component | heterochromatin | 2 | 0.039587501 | SALL1, CBX2 |
| Biological Process | G2 DNA damage checkpoint | 2 | 0.040893995 | CLSPN, CHEK1 |
| Biological Process | DNA replication | 3 | 0.041293616 | CLSPN, CHEK1, CDC25A |
| Biological Process | positive regulation of cardiac muscle cell proliferation | 2 | 0.044892884 | TGFBR3, FGF2 |
| Biological Process | establishment of cell polarity | 2 | 0.048875575 | WNT7A, WEE1 |