Table 2.

Correlations of TNFRSF9 methylation and mRNA expression with IFN-γ-signature. Correlations of TNFRSF9 methylation and mRNA expression with IFN-γ and IFN-γ-regulated genes (STAT1, STAT2, JAK2, and IRF9). DNA methylation was determined at twelve different loci targeted by HumanMethylation450 BeadChip beads (Fig. 1). Significant data are shown in boldface. Data were obtained from N = 468 (methylation) and N = 467 (mRNA expression) tumor samples, respectively.

		IFN-γ		STAT1		STAT2		JAK2		IRF9
Analyte	Bead no.	Spearman's ρ	P-value	Spearman's ρ	P-value	Spearman's ρ	P-value	Spearman's ρ	P-value	Spearman's ρ	P-value
mRNA	NA	0.85	<0.001	0.74	<0.001	0.31	<0.001	0.57	<0.001	0.47	<0.001
cg16839093	1	0.04	0.42	0.06	0.18	0.04	0.40	0.13	0.006	0.03	0.57
cg27305704	2	0.01	0.88	0.05	0.30	0.06	0.22	0.10	0.035	0.01	0.81
cg18859763	3	−0.08	0.084	−0.10	0.035	0.00	0.98	0.02	0.61	−0.06	0.24
cg07836592	4	−0.02	0.64	−0.02	0.74	0.01	0.80	0.10	0.026	−0.02	0.62
cg23959705	5	0.07	0.15	0.09	0.064	0.05	0.27	0.13	0.005	0.08	0.082
cg06956444	6	−0.44	<0.001	−0.40	<0.001	−0.07	0.12	−0.23	<0.001	−0.20	<0.001
cg14614416	7	−0.33	<0.001	−0.24	<0.001	−0.11	0.020	−0.14	0.002	−0.20	<0.001
cg18025409	8	−0.17	<0.001	−0.21	<0.001	−0.02	0.61	−0.10	0.035	−0.09	0.051
cg14153654	9	−0.07	0.13	−0.13	0.006	−0.02	0.70	0.00	0.99	−0.05	0.24
cg08840010	10	−0.32	<0.001	−0.31	<0.001	−0.14	0.002	−0.05	0.24	−0.27	<0.001
cg17123655	11	−0.35	<0.001	−0.36	<0.001	−0.07	0.12	−0.18	<0.001	−0.19	<0.001
cg16117781	12	−0.39	<0.001	−0.33	<0.001	−0.14	0.002	−0.24	<0.001	−0.19	<0.001

NA: Not Applicable.