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Signaling crosstalk with BMP9. Several major signaling events must take place in the BMP9-induced osteogenic differentiation of mesenchymal stem cells. The action of BMP9 results in a complicated albeit well-coordinated signaling cascade that results in gene transcription at precise steps of osteogenic differentiation. Cross talk between with BMP9 and other pathways such as the Wnt, Notch, and the other pathways shown results in augmentation of BMP9 signaling.
