Fig. 11.
Induction of M1 (Arg2) and M2 (MRC1) markers in MΦWT and MΦTg. Peritoneal macrophages isolated from 8-week-old WT and Tg mice were treated with vehicle [control (Con)], IFNγ + LPS, or IL-4. The cells were harvested and processed for real-time qPCR analyses. A: Arg2 (Control MΦWT and MΦTg 2−ΔΔCT, 2.21 ± 0.86 and 2.41 ± 0.39). B: MRC1 (Control MΦWT and MΦTg 2−ΔΔCT, 4.81 ± 2.91 and 15.38 ± 4.28). Data are mean ± SEM of fold-change relative to Con determined from four independent experiments. *MΦTg significantly different from MΦWT, P < 0.05.