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. 2019 Dec 5;61(2):229–243. doi: 10.1194/jlr.RA119000431

Fig. 3.

Fig. 3.

Bioinformatic analysis of the X. dendrorhous STP1 gene. A: Sequence analysis of the X. dendrorhous STP1 gene. The gene consists of five exons and encodes a predicted protein of 621 amino acids. B: Scheme of the predicted X. dendrorhous Stp1 protein in which the M50 peptidase domain (in orange) and the H-E-(X)2-H and N-(X)2-P-(X)4-D-G motifs (in yellow) are shown. The Stp1 protein TM segments were predicted with bioinformatic tools available online, and the consensus TM segments predicted by at least three tools are indicated. Protein domains were predicted with SMART (68) and TM segments with Phobius (69), SOSUI (70), TMHMM v. 2.0 (71), MINNOU (72), and TMpred (73). C: A sequence alignment of the M50 peptidase domain containing the conserved motifs H-E-(X)2-H and N-(X)2-P-(X)4-D-G from H. sapiens S2P protease [GenBank: AAC51937.1] and Stp1 from C. neoformans (CnStp1) [GenBank: XP_571333.1] and X. dendrorhous (XdStp1) [GenBank: MN380032] is shown.