TABLE 3.
Antibody | Study | IMC-infected cell ADCC endpoint concn (μg/ml) |
||||||
---|---|---|---|---|---|---|---|---|
AE.CM235 | B.WITO | C.TV-1 | C.MW96.5 | C1086.C | C.DU151 | C.DU422 | ||
A32 | 0.0006104 | 0.002097 | 0.0006104 | 0.009766 | 0.0009997 | 0.001628 | 0.009766 | |
CH38 | RV144 | 0.0006104 | 0.00675 | 0.001343 | 0.01723 | 0.008663 | 0.0333 | >40 |
CH57 | RV144 | 0.008608 | >40 | 5.368 | >40 | 9.307 | 0.1427 | 7.142 |
CH90 | RV144 | 0.06479 | 23 | 1.281 | >40 | >40 | 0.4033 | 4.474 |
CH54 | RV144 | 0.08913 | 1.079 | 0.1192 | >40 | 1.944 | 0.1169 | >40 |
DH677.1 | RV144 | 0.008816 | 1.01 | >40 | >40 | >40 | >40 | >40 |
DH677.3 | RV305 | 0.0007527 | 0.006146 | 0.002376 | 6.151 | 0.01439 | 0.02068 | 0.02528 |
DH697 | RV305 | 0.004967 | 0.03909 | 0.02134 | 0.0657 | 0.08982 | 0.1096 | 1.047 |
DH677.2 | RV305 | 0.002912 | 0.02705 | 0.01351 | >40 | 0.03581 | 0.5741 | >40 |
DH838 | RV305 | 0.0006104 | 0.008903 | 0.03242 | >40 | 0.005042 | >40 | >40 |
DH677.4 | RV305 | 0.00182 | 0.008885 | 0.03447 | 6.947 | 0.02838 | 0.3027 | >40 |
DH695 | RV305 | 0.005664 | 0.5867 | 0.07879 | 1.325 | 0.3076 | 0.3342 | 12.15 |
DH694 | RV305 | 0.0091 | 0.1159 | 0.1249 | >40 | 0.2651 | 1.854 | >40 |
DH688.1 | RV305 | 0.03942 | 0.09033 | 0.1375 | 8.079 | 0.3554 | 1.268 | >40 |
DH705.5 | RV305 | 0.0122 | 0.07738 | 0.09824 | >40 | 0.08681 | 0.3366 | >40 |
DH705.4 | RV305 | 0.03119 | 0.2424 | 0.1735 | 2.813 | 0.1999 | 1.8 | >40 |
DH886 | RV305 | 0.01321 | 0.1425 | 0.1367 | >40 | 1.583 | 0.1721 | >40 |
DH690 | RV305 | 0.09713 | 0.1758 | 0.3679 | 7.525 | 0.6221 | 2.862 | 4.34 |
DH692 | RV305 | 0.07932 | 0.1438 | 0.3851 | 5.228 | 0.1444 | 6.399 | >40 |
DH693 | RV305 | 0.01995 | 2.168 | 0.05216 | 0.8583 | 1.361 | 2.194 | 6.363 |
DH836 | RV305 | 0.02868 | 0.6244 | 0.1854 | >40 | 0.1397 | 12.02 | >40 |
DH688.2 | RV305 | 0.009277 | 0.1436 | 0.1338 | >40 | 0.5658 | 4.409 | >40 |
DH691 | RV305 | 0.03596 | 0.9201 | 0.465 | 8.113 | 0.6149 | 2.376 | >40 |
DH689.1 | RV305 | 0.352 | 1.629 | 1.69 | >40 | 4.817 | 9.348 | 30.49 |
DH689.2 | RV305 | 0.3429 | 2.225 | 0.4746 | >40 | 5.814 | 6.567 | 1.094 |
DH687.2 | RV305 | >40 | >40 | 20.61 | >40 | 2.033 | >40 | >40 |