TABLE 5.
Region | BSA (Å2) fora
: |
||
---|---|---|---|
DH677.3 fab-gp12093TH057 coree-M48U1 | A32 Fab- ID293TH057 (4YC2) | N12-i3 fab-gp12093TH057 coree+N/C-M48U1 (5W4L) | |
gp120 total | 925 | 850 | 803 |
7/8-stranded β-sheet | 248 | 0 | 754 |
Layer 1 | 542 | 645 | 49 |
Layer 2 | 135 | 205 | 0 |
Layer 3 | 0 | 0 | 0 |
Heavy chain total | 475 | 614 | 711 |
FWR | 0 | 17 | 16 |
CDR H1 | 16 | 103 | 39 |
CDR H2 | 84 | 83 | 440 |
CDR H3 | 375 | 411 | 216 |
Light chain total | 498 | 234 | 142 |
FWR | 95 | 0 | 0 |
CDR L1 | 238 | 126 | 10 |
CDR L2 | 27 | 0 | 0 |
CDR L3 | 138 | 108 | 132 |
Heavy- and light-chain total | 973 | 848 | 853 |
Details are based on the DH677.3-gp12093TH057coree -M48U1, A32 Fab-ID293TH057, and N12-i3 Fab-gp12093TH057coree+N/C-M48U1 structures, as calculated by the EBI PISA server (http://www.ebi.ac.uk/msd-srv/prot_int/cgi-bin/piserver). The two copies in the asymmetric unit of the DH677.3, A32, and N12-i3 complexes are averaged.