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Simultaneous delivery of CpG ODNs and aPD1 by DNC in the inflammatory environment (A) DNCs containing aPD1 and restriction enzyme cleaves under the action of inflammatory environment, releasing CpG and aPD1. (B) In vivo antitumor effect of local injection of the delivery system of DNCs (Scale bar: 150 µm). [reproduced with permission from (Wang et al., 2016)]. ODNs, Oligodeoxynucleotides; DNCs, DNA nano-cocoons; aPD1, anti-PD-1 antibodies.
