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. 2020 Jan 28;14:3. doi: 10.3389/fncel.2020.00003

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Copyright © 2020 Lapi, Stornaiuolo, Sabatino, Sommella, Tenore, Daglia, Scuri, Di Maro, Colantuoni and Novellino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The images of the pial microvascular networks obtained by computer-assisted method under baseline conditions (A), after restoration of cerebral blood flow (CBFR; B) and after Dichlorofluorescein (DCF) local administration (C) in a rat of SO-S group: there were no changes in the diameter of the microvessels, in microvascular leakage and in radical oxygen species (ROS) formation; in (D) the computer-assisted images of a rat of H group under baseline conditions, after CBFR (E) and after DCF local administration (F): the arterioles present reduction in diameter; the marked changes in the color of interstitium (from black to white) due to fluorescence dextran leakage; while the ROS formation were highlighted by numerous fluorescent spots. In (G), the computer-assisted images of the pial microvascular networks under baseline conditions, after CBFR (H) and after DCF (I) local administration in a rat treated with intravenous Taurisolo^®: no leakage of fluorescent-dextran and no ROS formation were detected. The computer-assisted images of the pial microvascular networks under baseline conditions (J), after CBFR (K) and after DCF local administration (L) in a rat treated with oral Taurisolo^®: neither permeability nor ROS formation were evident.