Figure 3.

Representative lung histology from vehicle and SIL-treated wild-type (WT) and Marfan syndrome (MFS; A and C) mice and combined mean linear intercept measurements (B). B: Gray shading indicates mice treated with sildenafil. Data are expressed as means ± SEM (B). n= 6 to 12 mice per group (B). ^∗∗∗P < 0.001 versus WT in the same treatment groups; ^††P < 0.01 versus untreated MFS (two-way analysis of variance with Sidak post-hoc test). Scale bars = 300 μm (A and C).