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. 2020 Jan 17;23(2):100848. doi: 10.1016/j.isci.2020.100848

Figure 8.

Figure 8

Pharmacological Inhibition of GPR4 Reduces Tissue Edema in the Inflammatory Hindlimb Ischemia-Reperfusion (IR) Mouse Model

(A and B) Upper and lower leg circumference changes following IR in wild-type (WT) mice treated with either vehicle or GPR4 antagonist 13. GPR4 antagonist 13 reduces the changes of upper and lower leg circumference when compared with vehicle control in the IR mouse model. Quantitative analysis of (A) upper and (B) lower leg circumference changes, respectively. N = 10 vehicle- and N = 10 GPR4 antagonist 13-treated mice. Data are presented as mean ± SEM and were analyzed for statistical significance using the ANOVA where *p < 0.05, **p < 0.01, and ***p < 0.001.