Table 1.

Thermodynamic Parameters of the Hsp90NMΔ:ADP and Hsp90NMΔ:AMPPNP Systems Measured by ITC Experiments

Ligand	Compound	N	Kd (μM)	ΔH (103 cal mol−1)	TΔS (103 cal mol−1)
ADP	DMSO	0.982 ± 0.06	7.3 ± 1.0	−11.96 ± 0.4	−4.84
	16–171	1.05 ± 0.02	3.4 ± 0.045	−7.99 ± 0.18	−0.41
	16–175	0.967 ± 0.03	6.3 ± 1.2	−8.37 ± 0.32	−1.16
AMPPNP	DMSO	1.04 ± 0.08	14.1 ± 4.6	−2.27 ± 0.24	4.45
	16–171	1.01 ± 0.07	10 ± 3.7	−1.68 ± 0.16	5.24
	16–175	0.92 ± 0.07	8.7 ± 3.4	−1.46 ± 0.16	5.54