Table 1:
In Vitro Antiviral Activity of EV-D68 MP0, EV-D68 MP30PP and Rhinovirus-14
| Compound | No
Virus CC50a |
EV-D68/Missouri (MP0) |
EV-D68/Missouri (MP30PP) |
Rhinovirus-14 | ||||
|---|---|---|---|---|---|---|---|---|
| RD | Hela-Ohio | EC50b | SIc | EC50b | SIc | EC50b | SId | |
| Enviroxime | 14.1 ± 4.8 | 22.3 ± 9.7 | 0.03 ± 0.0 | 469 | 0.07 ± 0.03 | 201 | 0.13 ± 0.1 | 108 |
| Pleconaril | 10.5 ± 3.5 | 4.7 ± 2.3 | 0.08 ± 0.0 | 131 | 0.08 ± 0.00 | 131 | 0.08 ± 0.0 | 59.1 |
| Guanidine | 1420 ± 315 | 3030. ± 577 | 44.7 ± 11.9 | 31.7 | 61.0 ± 10.5 | 23.3 | 80.7 ± 16.2 | 37.6 |
| Rupintrivir | >1.0 ± 0.0 | >1.0 ± 0.0 | 0.0003 ± 0.0 | >3333 | 0.0004 ± 0.0001 | >2500 | 0.003 ± 0.0004 | >333 |
Units in μM. Enterovirus D68 tested on RD cells, Rhinovirus-14 tested on Hela-Ohio cells.
a
50% cytotoxic concentration (CC50) ± standard deviation from 3 independent experiments.
b
50% effective virus-inhibitory concentration ± standard deviation from 3 independent experiments.
c
SI-Selectivity Index = CC50 / EC50 using the CC50 in RD cells.
d
SI-Selectivity Index = CC50 / EC50 using the CC50 in Hel-Ohio cells