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. Author manuscript; available in PMC: 2020 Feb 4.
Published in final edited form as: Sci Signal. 2019 Apr 23;12(578):eaav3810. doi: 10.1126/scisignal.aav3810

Table 3. List of novel pseudokinase families.

Representative members of novel pseudokinase families are listed.

PsK family Kinase
family
Kinase
group
Example member(s)
TK-Unclassified TK Camponotus floridanus putative tyrosine-protein kinase Wsck (E2ACX7_CAMFO)
LysM IRAK TKL Arabidopsis thaliana LYK5/LysM-containing receptor-like kinase 5/At2g33580 (LYK5_ARATH)
LysM-Iike IRAK TKL Arabidopsis thaliana Protein kinase superfamily protein/At3g57120 (Q8VYG5_ARATH)
DLSV IRAK TKL Arabidopsis thaliana Cysteine-rich receptor-like protein kinase 45/Cysteine-rich RLK45/At4g11890 (CRK45_ARATH)
RLCKXII-2/WAK IRAK TKL Arabidopsis thaliana Non-functional pseudokinase ZED1/hopZ-ETI-deficient 1/At3g57750 (ZED1_ARATH)
CrRLK1-Iike IRAK TKL Cajanus cajan Receptor-like protein kinase ANXUR2/KK1_043523 (A0A151QYL0_CAJCA)
LRRIII IRAK TKL Arabidopsis thaliana PRK1/Pollen receptor-like kinase 1/At5g35390 (PRK1_ARATH)
LRRV IRAK TKL Arabidopsis thaliana SUB/STRUBBELIG/At1g11130 (SUB_ARATH)
LRRVI-1 IRAK TKL Arabidopsis thaliana Leucine-rich repeat protein kinase family protein/MUA22.21/At5g14210 (A0A178US29_ARATH)
LRRVI-2 IRAK TKL Arabidopsis thaliana MDIS1/Male discoverer 1/At5g45840 (MDIS1_ARATH)
Rig1 TKL Rhizophagus irregularis Rad53p/RirG_173180 (A0A015K1H5_9GLOM)
Rig2 TKL Rhizophagus irregularis Skt5p/RirG_180750 (A0A015 ISZ5_9GLOM )
Rig3 TKL Rhizophagus irregularis Ssk22p/RirG_232660 (A0A015 IBX1_9GLOM )
FunTKL1 TKL Rhizoctonia solani Uncharacterized protein/RSAG8_12895 (A0A066UWY2_9HOMO)
FunTKL2 TKL Penicillium subrubescens Uncharacterized protein/PENSUB_13048 (A0A1Q5SUF1_9EURO)
IRAK-Unclassified TKL Arabidopsis thaliana BIR2/BAK1-interacting receptor-like kinase 2/At3g28450 (BIR2_ARATH)
STE11-like STE Arabidopsis thaliana Protein kinase superfamily protein/At2g40580 (O22877_ARATH)
STE-Unclassified AGC Homo sapiens Uncharacterized protein (A0A1B0GUL7_HUMAN); Pan troglodytes Uncharacterized protein (A0A2I3RK43_PANTR)
AGC-Unclassified AGC Paramecium tetraurelia hypothetical protein/GSPATT00021006001 (A0DWE7_PARTE)
CAMK-Unclassified CAMK Paramecium tetraurelia Uncharacterized protein/GSPATT00003535001 (A0E5V5_PARTE)
PFunC CMGC Sorghum bicolor Uncharacterized protein/SORBI_3005G165300 (A0A1Z5RK15_SORBI)
FunC1 CMGC Penicillium patulum Uncharacterized protein/PGRI_024730 (A0A135LI09_PENPA)
FunC2 CMGC Penicillium subrubescens SRSF protein kinase 3/PENSUB_10992 (A0A1Q5T6W4_9EURO)
FunC2-like CMGC Coprinopsis cinerea CMGC/SRPK protein kinase/CC1G_09673 (A8P9H1_COPC7)
NemaRGC RGC Other Caenorhabditis elegans Receptor-type guanylate cyclase gcy-1/AH6.1 (GCY1_CAEEL)
RGC-like RGC Other Amphimedon queenslandica Guanylate cyclase (A0A1X7VH93_AMPQE)
CWNK WNK Other Homo sapiens WNK1/Protein kinase with no lysine 1 (WNK1_HUMAN)
PWNK WNK Other Arabidopsis thaliana AtWNK1/Protein kinase with no lysine 1/At3g04910 (WNK1_ARATH)
WNK-Unclassified WNK Other Caenorhabditis elegans Serine/threonine-protein kinase WNK/Protein kinase with no lysine 1/C46C2.1 (WNK_CAEEL)
Cili-like Other Neurospora crassa Mitotic spindle checkpoint component mad3/NCU10043 (V5IRN2_NEUCR)
MetaPAN3 PknB Homo sapiens PAN3/Poly(A)-nuclease deadenylation complex subunit 3 (PAN3_HUMAN)
Bac1 PknB Streptomyces aurantiacus JA 4570 Uncharacterized protein/STRAU_1734 (S3ZNQ3_9ACTN)
Bac2 PknB Frankia sp. EI5c Serine/threonine protein kinase /UG55_100447 (A0A166T1F0_9ACTN)
Bac3 PknB Trichodesmium erythraeum (strain IMS101) Serine/threonine protein kinase with TPR repeats/Tery_4781 (Q10VJ1_TRIEI)
Act PknB Streptomyces sp. NTK 937 Aminoglycoside phosphotransferase/DT87_12690 (A0A069K2D6_9ACTN)
MviN PknB Mycobacterium shimoidei Transmembrane serine/threonine-protein kinase D PknD/STPK D/BHQ16_10175 (A0A1E3TG29_MYCSH)
LanC PknB Streptomyces vietnamensis Uncharacterized protein /SVTN_34785 (A0A0B5I836_9ACTN)
DYD PknB Frankia sp. (strain EANlpec) Nucleic acid binding OB-fold tRNA/helicase-type/Franean1_4264 (A8L9E5_FRASN)
HGA PknB Actinosynnema mirum (strain ATCC 29888) Uncharacterized protein/Amir_3792 (C6WD53_ACTMD)
B3A PknB Lentisphaera araneosa HTCC2155 Serine/threonine-protein kinase/LNTAR_17493 (A6DFI7_9BACT)
PASTA PknB Firmicutes bacterium CAG:94 PASTA domain protein/BN815_00934 (R6ZDX7_9FIRM)
NERD PknB Singulisphaera acidiphila (strain ATCC BAA-1392) Nuclease-like protein/protein kinase family protein/Sinac_1959 (L0DAB9_SINAD)
TCS PknB Rhodopirellula islandica Two-component signal transduction/RISK_006087 (A0A0J1B5P6_RHOIS)