Skip to main content
. 2020 Jan 21;30(1):116–132. doi: 10.1089/thy.2019.0175

FIG. 7.

FIG. 7.

T3 inhibits E2-dependent proliferation and autocrine FGF induction. (A) MCF-7 and MCF7-TRβ cells were cultured under adherent conditions in the presence and absence of E2 and/or T3, as indicated in 6-well plates. Cells were counted three, six, and nine days after inoculation. Data are mean ± SD, and differences between T3-treated and T3-untreated cells are indicated with asterisks. (B) FGF9 transcripts in cells treated for nine days with E2 and/or T3 as indicated. Data are mean ± SD and are expressed relative to the levels obtained in MCF-7 untreated cells. Statistically significant differences between MCF-7 and MCF7-TRβ cells in each condition are shown. (C) FGF9, FGFR3, and FGFR4 mRNA levels were determined in cells treated with and without T3 for 72 h. Data (mean ± SD) are expressed relative to the levels obtained in the untreated cells, and differences between treated and untreated cells are indicated. *p < 0.05, **p < 0.01, and ***p < 0.001. FGF, fibroblast growth factor.