Table 3.
Descriptive data, mothers’ disease, smoking history and pregnancy outcomes in maternal IBD compared to controls, from MoBa 2002–2008
| Non-IBD (%) | IBD (%) | *P-value | CD (%) | *P-value | UC (%) | *P-value | ||
|---|---|---|---|---|---|---|---|---|
| PPDS, ranked in quartiles (q1-q4) | Group 1 (q1 + q2) (0.0–0.21) | 34,241(49.8) | 222 (64.9) | < 0.001 | 95 (64.2) | < 0.001 | 127 (65.5) | < 0.001 |
|
Group 2 (q3) (0,21-0,27) |
17,516 (25.5) | 70 (20.5) | 35 (23.6) | 35 (18.0) | ||||
|
Group 3 (q4) (0,27–0.93) |
17,068 (24.8) | 50 (14.6) | 18 (12.2) | 32 (16.5) | ||||
| Age | N (mean, std) | 30.3 (4.5) | 30.6 (4.2) | 0.16 | 30.1 (4.5) | 0.62 | 31.0 (4.1) | 0.02 |
| Education | High school or less | 21,254 (32.4) | 98 (30.5) | 0.12 | 47 (33.8) | 0.32 | 51 (28.0) | 0.18 |
| College 3 years | 27,966 (42.7) | 155 (48.3) | 65 (46.8) | 90 (49.5) | ||||
| Master or higher | 16,278 (24.9) | 68 (21.2) | 27 (19.4) | 41 (22.5) | ||||
| Diabetes | yes | 981 (1.4) | 3 (0.9) | 0.34 | 1 (0.5) | 0.44 | 2 (1.0) | 0.65 |
| no | 67,844 (98.6) | 339 (99.1) | 182 (99.5) | 192 (99.0) | ||||
| Hypertension | yes | 3958 (5.8) | 18 (5.3) | 0.90 | 10 (5.5) | 0.86 | 10 (5.2) | 0.72 |
| no | 64,867 (94.2) | 324 (94.7) | 173 (94.5) | 184 (94.8) | ||||
| Smoking history | Current | 4680 (7.5) | 25 (7.9) | 0.59 | 22 (12.7) | 0.032 | 8 (4.5) | 0.14 |
| Never | 58,083 (92.5) | 291 (92.1) | 151 (87.3) | 169 (95.5) | ||||
| BMI categories | BMI < 18.5 | 1963 (2.9) | 12 (3.5) | 0.28 | 7 (3.9) | 0.24 | 6 (3.1) | 0.78 |
| 18.5 ≤ BMI < 24.9 | 45,202 (65.8) | 238(69.8) | 123 (69.1) | 133 (68.9) | ||||
| 25 ≤ BMI < 29.9 | 15,086 (22.0) | 68 (19.9) | 37 (20.8) | 39 (20.2) | ||||
| BMI > 30 | 6429 (9.4) | 23 (6.7) | 11 (6.2) | 15 (7.8) | ||||
| GWG | N (mean, std) | 68,680 (14.8, 9.2) | 342 (13.8, 6.3) | 0.049 | 13.5 (6.8) | 0.09 | 14.07 (5.9) | 0.26 |
| Inadequate GWG | yes | 13,211 (19.2) | 104 (30.5) | < 0.001 | 52 (35.1) | < 0.001 | 52 (26.9) | 0.007 |
| no | 55,469 (81.8) | 237 (69.5) | 96 (64.9) | 141 (73.1) | ||||
| SGA | yes | 4425 (6.5) | 31 (9.1) | 0.03 | 15 (10.1) | 0.07 | 16 (8.2) | 0.31 |
| no | 64,091 (93.5) | 311 (90.8) | 133 (89.9) | 178 (91.8) | ||||
| Disease activity | yes | N/A | 58 (13.7) | 16 (8.7)) | 42 (17.5) | |||
| no | N/A | 270 (86.3) | 120 (91.3) | 150 (82.5) | ||||
| Total energy intake - kcal | N (mean, std) | 2298 (601) | 2285 (607) | 0.70 | 2319 (663) | 0.66 | 2258 (587) | 0.37 |
| BMI continuous | N (mean, std) | 24.0 (4.2) | 23.5 (3.8) | 0.02 | 23.2 (3.9) | 0.026 | 23.7 (3.8) | 0.29 |
BMI Body mass index, GWG Gestational weight gain, PPDS Proportion of protein from dairy sources, SGA Small for gestational age
Plural birth, extreme energy intake and 50 kg < GWG < −30 kg excluded *p-values of chi squared tests comparing categorical variables between non-IBD and IBD/CD/UC