Table 2.
PRV-specific neutralizing antibody (NA) and PPV-specific HI antibody (Log 2)a levels in mice
| Group | Weeks post the first vaccination | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 2 | 4 | 6 | 8 | ||||||
| NA | HI | NA | HI | NA | HI | NA | HI | NA | HI | |
| rPRV-VP2-IL6 | -b | 0 | 1:2 | 2.5 ± 0.2* c | 1:8 | 4.1 ± 0.3* | 1:32 | 5.3 ± 0.2* | 1:128 | 6.9 ± 0.3* |
| rPRV-VP2-EGFP | – | 0 | 1:2 | 2.0 ± 0.2* | 1:8 | 3.9 ± 0.2* | 1:32 | 5.0 ± 0.3* | 1:64 | 6.5 ± 0.2* |
| PPV vaccine | – | 0 | – | 4.0 ± 0.3* | – | 6.3 ± 0.3* | – | 5.6 ± 0.2* | – | 7.6 ± 0.3* |
| PRV HB98 | – | 0 | 1:2 | 0 | 1:8 | 0 | 1:32 | 0 | 1:128 | 0 |
| DMEM | – | 0 | – | 0 | – | 0 | – | 0 | – | 0 |
aValues are expressed as mean HI antibody titer ± standard error
bNA titers <2
cStatistically significant differences (P < 0.05) are indicated by*(compared with compared with PRV HB98 or DMEM)