Table 3.
Risk of poor outcome at 12 months by FI quartiles
| Population | Quartile 1 (FI < 0.23) | Quartile 2 (FI 0.23–0.31) | Quartile 3 (FI 0.32–0.40) | Quartile 4 (FI ≥ 0.41) | P-for-trend |
|---|---|---|---|---|---|
| Combined, n/N (%) 44/228 (19.3%) | 2/55 (3.6%) | 6/58 (10.3%) | 14/56 (25.0%) | 22/59 (37.3%) | |
| Unadjusted OR (95% CI) | Ref | 3.1 (0.6–15.8) | 8.8 (1.9–41.0) | 15.8 (3.5–71.1) | < 0.001 |
| Adjusted OR (95% CI)a | Ref | 2.6 (0.5–13.9) | 7.2 (1.5–34.5) | 13.2 (2.8–61.1) | < 0.001 |
| SAVR, n/N (%) 5/91 (5.5%) | 1/44 (2.3%) | 1/23 (4.4%) | 3/19 (15.8%) | 0/5 (0%) | |
| Unadjusted OR (95% CI) | Ref | 2.0 (0.1–32.8) | 8.1 (0.8–83.3) | Not estimated | 0.24 |
| Adjusted OR (95% CI)a | Ref | 1.3 (0.1–26.0) | 4.4 (0.4–49.5) | Not estimated | 0.53 |
| TAVR, n/N (%) 39/137 (28.5%) | 1/11 (9.1%) | 5/35 (14.3%) | 11/37 (29.7%) | 22/54 (40.7%) | |
| Unadjusted OR (95% CI) | Ref | 1.7 (0.2–16.0) | 4.2 (0.5–37.2) | 6.9 (0.8–57.6) | 0.004 |
| Adjusted OR (95% CI)a | Ref | 1.6 (0.2–16.0) | 3.9 (0.4–34.8) | 6.6 (0.8–55.9) | 0.004 |
aNote: adjusted models include age and sex
Abbreviations: CI confidence interval, FI frailty index, OR odds ratios, SAVR surgical aortic valve replacement, TAVR transcatheter aortic valve replacement