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. 2020 Feb 4;20:56. doi: 10.1186/s12872-020-01365-9

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Modulating autophagy and cardiac matrix remodeling of DCM. (A) Picrosirius red staining indicated significantly changes of collagen distribution in the four different groups. (B) Histochemical analysis showed that there was a significant increase of collagen distribution in the DCM group compared with the control group. Quantitative assessment demonstrated that the CVF was significantly decreased in the rapamycin group, and it was increased in the 3-MA group compared with the DCM group. ^†††P < 0.001 vs Control, ^**P < 0.01 and ^#P < 0.05 vs DCM. Scale bar = 100 μm