Table 2.
Distribution and hazard ratio of hospitalization for motor vehicle accident injury in OSA patients
| OSA vs No OSA (N) | 3025 | 9075 |
| MVA injury* N (%) | 172 (5.7%) | 358 (3.97%) |
| per 105 person-year | 575.3 | 392.0 |
| Crude HR (reference: non-OSA) | 2.35 (95% CI: 1.96–2.81) *** | |
| Adjusted HR (reference: non-OSA) | 2.18 (95% CI: 1.79–2.64) *** | |
| Male (reference: female), adjusted HR | 1.48 (95% CI: 1.18–1.71) *** | |
| CCI, adjusted HR | 1.57 (95% CI: 1.55–1.59) *** | |
| Comorbidities (reference: without), adjusted HR | ||
| Insomnia | 2.96 (95%CI: 1.43–5.33) *** | |
| Idiopathic hypersomnia | 18.22 (95%CI 0.45–167.21) | |
| Circadian rhythm sleep disorder, shift work type | No MVA injury events | |
| Anxiety disorders | 5.11 (95%CI: 3.98–7.66) *** | |
| Depressive disorders | 4.35 (95%CI: 2.06–6.53) *** | |
| Bipolar disorders | 3.38 (95%CI: 2.11–4.79) *** | |
| Psychotic disorders | 2.64 (95%CI: 1.29–3.86) *** | |
| Restless leg syndrome | No MVA injury events | |
| Periodic limb movement disorder | No MVA injury events | |
| Alcohol-related disorders | 5.71 (95%CI: 2.63–8.82) *** | |
| Other substance-related disorders | 3.59 (95%CI: 1.11–4.94) * | |
| Medications (reference: without), adjusted HR | ||
| Hypnotics (Z-drugs and benzodiazepine) | 2.31 (95%CI: 1.84–2.98) *** | |
| Antihistamines | 1.30 (95%CI: 1.01–1.62) * | |
| Antidepressants | 1.64 (95%CI: 1.24–2.13) ** | |
| Antipsychotics | 1.81 (95%CI: 1.31–2.20) *** | |
OSA obstructive sleep apnea, MVA motor vehicle accidents, HR hazard ratio, CCI Charlson comorbidity index; Adjusted for the variables listed in Table 1
* P < 0.05, ** P < 0.01, *** P < 0.001