Table 1.
Characteristics of studies included in this meta-analysis.
| Authors | Country | Type of sample | Study design | Type of cancer | Expression of ciRS-7∗∗∗ | Cutoff value | Sample size | NOS score | Follow-up | HR (95% CI) for OS | Detection method | Analysis method |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jiang et al. [26] | China | Tissue | Retrospective | CCA | Upregulation | NR | 54 | 6 | NR | 1.887 (1.025–3.474) | qRT-PCR | M |
| Weng et al. Training cohort [19] | China | Tissue | Retrospective | CRC | Upregulation | Median | 153 | 8 | 3.7y-median | 1.8689 (1.0977–3.9023) | qRT-PCR | M |
| Weng et al. Validation cohort [19] | Japan | Tissue | Retrospective | CRC | Upregulation | Median | 165 | 8 | 5.1y-median | 2.7262 (1.0879–6.8315) | qRT-PCR | M |
| Tang et al. [21] | China | Tissue | Retrospective | CRC | Upregulation | Median | 182 | 6 | NR | 1.799 (1.055–3.068) | qRT-PCR | U |
| Pan et al. Training cohorts [23] | China | Tissue | Prospective | GC | Upregulation | Median | 102 | 6 | NR | 2.11 (1.1610–3.8348) | qRT-PCR | U |
| Pan et al. Validation cohort [23] | China | Tissue | Prospective | GC | Upregulation | Median | 154 | 6 | NR | 2.63 (1.3177–5.2493) | qRT-PCR | U |
| Su et al. [24] | China | Tissue | Retrospective | NSCLC | Upregulation | Mean | 128 | 6 | NR | 1.705 (1.02–2.86) | qRT-PCR | M |
| Zhang et.al. [22] | China | Tissue | Retrospective | NSCLC | Upregulation | Median | 60 | 7 | NR | 6.132 (2.923–7.556) | qRT-PCR | M |
| Li et al. [29] | China | Tissue | Retrospective | ESCC | Upregulation | Median | 123 | 7 | NR | 2.70 (1.55–4.71) | qRT-PCR | U∗∗ |
| Uhr et al. [27] | Netherlands | Tissue | Retrospective | BC | Upregulation | Median | 345 | 8 | 91m-median | 1.03 (0.90–1.17) | qRT-PCR | U |
| Yan et al. [18] | China | Tissue | Retrospective | NSCLC | Upregulation | Median | 132 | 8 | 46m-median | 1.575 (1.016–2.440) | qRT-PCR | M |
| Zhang J et al. [28] | China | Tissue | Retrospective | LSCC | Upregulation | NR | 30 | 6 | NR | 4.026 (1.144–14.178) | qRT-PCR | U |
| Sang et al.∗[30] | China | Tissue | Retrospective | ESCC | Upregulation | Median | 86 | NR | NR | NR | qRT-PCR | NR |
CCA, cholangiocarcinoma; CRC, colorectal cancer; GC, gastric cancer; NSCLC, non-small-cell lung cancer; BC, breast cancer; LSCC, laryngeal squamous cell carcinoma; ESCC, esophageal squamous cell carcinoma; NR, not reported; qRT-PCR, quantitative real-time-PCR; U, univariate analysis; M, multivariate analysis; ∗the study only reporting the association between ciRS-7 expression and tumor stage, no survival data; ∗∗HR and corresponding 95% CIs were extracted from the survival curve; ∗∗∗compared with the normal tissue.