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. 2020 Jan 28;11:50. doi: 10.3389/fimmu.2020.00050

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Copyright © 2020 Kim, Je, Song, Fei, Lee, Yang, Kang, Jang, Seo and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of SG-SP1 on inflammatory cytokine expression. RBL-2H3 and BMMCs were sensitized with anti-DNP IgE. After incubation overnight, the cells were pretreated with or without drugs including SG-SP1, GA, and Dexa for 1 h and then challenged with DNP-HSA. (A) The expression of inflammatory cytokine genes was determined by qPCR. (B) The secretion of inflammatory cytokines was measured by ELISA. Data were presented as the means ± SEM of three independent experiments. *, **, and *** indicate statistically significant differences from the DNP-HSA-challenged group at a value of p < 0.05, 0.01, and 0.001, respectively.