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. 2020 Feb 3;13:12. doi: 10.1186/s13048-020-0615-0

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Age-dependent declines in the ovarian index and E₂ secretion in rats. (a) Ovarian index (ratio of ovarian weight to body weight). (b) Secretion of E₂. E₂: estradiol. The ovarian index values and the serum E₂ levels of 12 M and 24 M rats were significantly lower than those of 6 M rats. 6 M: 6-month-old, 12 M:12-month-old, 24 M:24-month-old. Compared with 6 M rats, **P < 0.01,***P < 0.001,****P < 0.0001; compared with 12 M rats, ^##P < 0.01