Table 1.
General characteristics, noise exposure, and genotype distribution between NIHL and control groups
| Characteristics | Total (n = 614) | NIHL (n = 307) | Control (n = 307) | χ2/z | P |
|---|---|---|---|---|---|
| Sex, n (%) | 0.000 | 1.000 | |||
| Male | 474 (77.2) | 237 (38.6) | 237 (38.6) | ||
| Female | 140 (22.8) | 70 (11.4) | 70 (11.4) | ||
| Age, M (P25~P75), y | 35 (30–43) | 36 (30–43) | 34 (30–42) | − 1.959 | 0.050 |
| Education, n (%) | |||||
| High School/University | 347 (56.5) | 168 (27.4) | 179 (29.2) | 0.802 | 0.371 |
| Below high school | 267 (43.5) | 139 (22.6) | 128 (20.8) | ||
| Years of exposure, M (P25~P75), y | 3.00 (1.43–6.00) | 3.00 (1.20–6.00) | 3.00 (2.00–6.00) | −1.002 | 0.317 |
| Threshold shift, dB | 25.00 (17.83–36.96) | 36.83 (29.83–49.83) | 17.83 (14.17–21.00) | −21.442 | <0.001 |
| Kurtosis, M (P25~P75) | 16.10 (9.99–28.33) | 17.10 (11.17–32.45) | 14.76 (9.23–24.95) | −2.810 | 0.005 |
| Steady noise | 154 (25.1) | 61 (9.9) | 93 (15.1) | 8.875 | 0.003 |
| Complex noise | 460 (74.9) | 246 (40.1) | 214 (34.9) | ||
| CNE, M (P25~P75), d B (A) | 93.69 (89.48–97.57) | 93.73 (89.67–98.24) | 93.62 (89.07–96.88) | −1.230 | 0.219 |
| <85 | 52 (8.5) | 28 (4.6) | 24 (3.9) | 0.336 | 0.562 |
| ≥ 85 | 562 (91.5) | 279 (45.4) | 283 (46.1) | ||
| rs12195525, n (%) | 4.041 | 0.133 | |||
| Additive | |||||
| GG | 516 (84.0) | 267 (43.5) | 249 (40.6) | ||
| GT | 87 (14.2) | 35 (5.7) | 52 (8.5) | ||
| TT | 11 (1.8) | 5 (0.8) | 6 (1.0) | ||
| Dominant | |||||
| GG | 516 (84.0) | 267 (43.5) | 249 (40.6) | 3.934 | 0.047 |
| TT + GT | 98 (16.0) | 40 (6.5) | 58 (9.4) | ||
| Recessive | |||||
| GG + GT | 603 (98.2) | 302 (49.2) | 301 (49.0) | 0.093 | 0.761 |
| TT | 11 (1.8) | 5 (0.8) | 6 (1.0) | ||
| Allele | |||||
| G | 1119 (91.1) | 568 (46.3) | 551 (44.9) | 2.910 | 0.088 |
| T | 109 (8.9) | 46 (3.7) | 63 (5.1) | ||