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. 2020 Feb 4;7(1):015006. doi: 10.1117/1.NPh.7.1.015006

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© 2020 The Authors

Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Fig. 8 — Demonstration of retinal layer abnormalities. The OPL is indicated with arrows. (a) A transgenic mouse retina with a typical appearance—the outer plexiform layer appears as one single hyper-reflective band. (b) H&E-stained histological slice of the same mouse retina as in (a). (c) A transgenic mouse retina with the OPL disrupted, appearing as a double-banded hyper-reflective layer. This effect was observed in 3/24 transgenic mice. (d) A similar double-banding effect was also observed in 3/15 wild-type littermates. (e) H&E-stained histological slice of the same mouse retina as in (d). The structural correlate of the double-banded OCT signal in the OPL region appears to be rearranged proximal outer nuclear layer somata. RNFL, retinal nerve fiber layer; GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; IS/OS, inner/outer segment junction; RPE, retinal pigment epithelium; BM, Bruch’s membrane; CH, choroid; and SC, sclera. Age: (a)–(b) 94 weeks and (c)–(e) 81 weeks.