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letter
. 2020 Feb 1;201(3):371–374. doi: 10.1164/rccm.201906-1217LE

Figure 1.

Figure 1.

Exogenous estrogen treatment is protective for pulmonary arterial mechanics after Sugen/hypoxia (SuHx) exposure. (A) Right ventricular systolic pressure (RVSP) was measured via closed-chest right-heart catheterization in intact females (Intact) and ovariectomized females with continuous 17β-estradiol (E2) repletion (OVX+E2) or placebo (OVX+Veh) before either normoxia (Norm) or SuHx exposure; n = 3–8 per group. (B) The pulmonary vascular impedance magnitude (Z) was measured (logarithmic scale on the y-axis) for varying pulsatile flow frequencies in Intact, OVX+E2, and OVX+Veh isolated rat lungs after either Norm or SuHx exposure; n = 4–9 per group. (C) The transpulmonary gradient was measured for varying flow rates in Intact, OVX+E2, and OVX+Veh isolated rat lungs after either Norm or SuHx exposure; n = 4–9 per group. (D) Distal pulmonary artery distensibility in Intact, OVX+E2, and OVX+Veh isolated rat lungs after Norm or SuHx exposure; n = 4–9 per group. *P < 0.05 versus Norm and SuHx-OVX+E2.