Antimicrobial resistance is a serious global threat necessitating reduction of inappropriate use of antimicrobials, which is prevalent in the outpatient setting.

Globally, significant misconceptions are present in the general public’s knowledge of antibiotics and their appropriate use.

Health literacy is an underutilized but valuable way to enhance provider–patient communication and improve antimicrobial stewardship (AMS) in the outpatient setting.

Four core elements to enhance AMS health literacy, based on the Centers for Disease Control and Prevention’s framework, are provided: (1) leadership commitment, (2) intervention/action, (3) tracking/reporting, and (4) education/expertise.

Several methods and tools to bolster AMS health literacy are described.