Table 5.

Drug-associated costs (€) in the population

Drugs and cost drivers	Screening	Year 1	Year 2	Year 3	Year 4	Sum	Difference to cladribine
Cladribine
Adverse event	0	6637	6637	6637	6637	26,548	NA
Drug acquisition	0	9,625,384	9,625,384	0	0	19,250,767	NA
Monitoring	140,337	129,016	98,102	89,600	89,600	546,655	NA
Productivity loss	20,001	26,062	32,411	13,363	13,363	105,200	NA
Travelling	12,965	14,942	17,013	10,799	10,799	66,519	NA
Sum	173,303	9,802,041	9,779,547	120,399	120,399	19,995,689	NA
Fingolimod
Adverse event	0	4074	4074	4074	4074	16,295	− 10,253
Drug acquisition	0	5,991,017	5,871,284	5,871,284	5,871,284	23,604,868	4,354,101
Monitoring	107,708	328,946	93,554	93,554	93,554	717,316	170,662
Productivity loss	20,001	83,153	19,657	19,657	19,657	162,125	56,925
Travelling	12,965	42,304	12,853	12,853	12,853	93,826	27,308
Sum	140,674	6,449,493	6,001,421	6,001,421	6,001,421	24,594,430	4,598,742
Natalizumab
Adverse event	0	0	0	0	0	0	− 26,548
Drug acquisition	0	7,560,000	7,560,000	7,560,000	7,560,000	30,240,000	10,989,233
Drug administration	0	1,043,902	1,043,902	1,043,902	1,043,902	4,175,607	4,175,607
Monitoring	110,746	89,600	89,600	131,892	131,892	553,730	7075
Productivity loss	19,049	165,089	165,089	177,788	177,788	704,801	599,602
Travelling	12,654	137,578	137,578	141,721	141,721	571,252	504,733
Sum	142,449	8,996,169	8,996,169	9,055,302	9,055,302	36,245,390	16,249,701
Treatment mix
Adverse event	0	3259	3259	3259	3259	13,036	− 13,512
Drug acquisition	0	6,304,814	6,209,027	6,209,027	6,209,027	24,931,894	5,681,127
Drug administration	0	208,780	208,780	208,780	208,780	835,121	835,121
Monitoring	108,316	281,077	92,763	101,221	101,221	684,599	137,944
Productivity loss	19,811	99,540	48,743	51,283	51,283	270,660	165,460
Travelling	12,903	61,359	37,798	38,626	38,626	189,312	122,793
Sum	141,029	6,958,828	6,600,370	6,612,197	6,612,197	26,924,622	6,928,934