Table 6.

Per-patient results of the sensitivity analyses covering all PICOSTEPS components (€)

Analysis	Cladribine tablets	Fingolimod (difference to cladribine tablets)	Natalizumab (difference to cladribine tablets)	Treatment mix (difference to cladribine tablets)
Base case	71,413	16,424	58,035	24,746
50% of patients women	72,468	15,369	56,980	23,691
90% of patients women	70,550	17,287	58,898	25,609
Age of the population 36 years	72,585	15,252	56,863	23,574
Patient weight based on Finnish real-life distribution instead of on an average	72,065	15,772	57,382	24,094
Annual adherence drop 10% after 1st year	67,976	7280	43,035	14,431
No screening costs	70,794	16,541	58,145	24,861
Time horizon 3 years	70,983	− 4580	26,124	1561
Fingolimod utilization: 14 28-tablet packs during the 1st year, 13 packs thereafter	71,413	17,609	58,035	25,694
Natalizumab utilization: 14 administrations during the 1st year, 13 administrations thereafter	71,413	16,424	71,254	27,390
Cost of natalizumab administration €934.50	71,413	16,424	88,020	30,743
Cost of natalizumab administration €373.00	71,413	16,424	61,068	25,353
All cost inputs -20%	57,131	13,139	46,428	19,797
All cost inputs +20%	85,696	19,709	69,642	29,695
24% of cladribine users assumed to switch to fingolimod on the fourth year	76,959	10,879	52,489	19,201
Direct costs only	71,037	16,221	55,893	24,155
Direct costs only, no travelling costs	70,800	16,123	54,091	23,717