Figure 1.

Schematic overview of methods to determine growth‐rate dependent product formation. In a chemostat experiment, product formation can be measured at a limited number of steady. The adapta‐stat is a chemostat with a smooth change of the dilution rate, which allows measurements in a quasi‐steady‐state. In fed‐batch cultures with constant feeding, the growth rate decreases abruptly once substrate limitation is reached. When monitoring cell density and product accumulation over time, a relation between μ and q_P can be drawn.