Figure 2.

(A) PLS model with principal component 1 (PC 1) and principal component 2 (PC 2) (R ²X: 0.90; R ²Y:0.47; Q ²: 0.27) derived from the 2D FL data over time of all P‐media batches. The addition of basal powder and Component 4 led to strong changes in the 2D FL signal during the preparation. (B) PLS model with principal component 1 (PC 1) and principal component 2 (PC 2) (R ²X: 0.56; R ²Y:0.83; Q ²: 0.72) derived from the MIR data over time of all P‐media batches. Data were preprocessed via Savitzky‐Golay (SG) and 2^nd derivative. Changes in the MIR profile could be detected mainly after addition of basal powder, bicarbonate, glucose, Component 4, organic acid, and water for injection (WFI). A detailed description of the Figure legend is presented in Table 2. Q ², goodness of prediction; R ², goodness of fit