Table 2.

Stimuli responsive or ligand conjugated organic‐inorganic hybrid silicas for therapeutic or diagnostic purposes

Target cell/animal	Therapy or imaging agent		Nanoparticle/bioconjugate type and triggering factors	Ref.
Stimuli responsive organic‐inorganic hybrid silicas
A549	DOX	–	Organic‐inorganic hybrid mesoporous nanoparticles with pH‐ and GSH‐ responsiveness	55
–		Rhodamine B	Fluorescent pH‐sensing organic/inorganic hybrid mesoporous silica nanoparticles	53
–		Rhodamine 6G	Mesoporous SiO2 films, functionalized with high quantities of azochromophores as photodriven nanoimpellers	52
KB‐V1	DOX and siRNA	–	PEI coated mesoporous silica nanoparticles	30
Ligand conjugated organic‐inorganic hybrid silica nanomaterials
U87 MG HEK 293	DOX		GNPs@RGD peptide‐capped MSNs	59
HCT116 mice	5‐Fluorouracil	‐	MSN‐P(OEGMAa‐co‐ RGD peptide	89
HeLa HEK 293	DiIb and DiOc as model drugs	‐	Folic acid‐conjugated and PEI‐functionalized MSNs	90
HeLa MCF‐7	Camptothecin		Tumor homing and penetrating peptide (tLyP‐1) functionalized MSNs	91

^apoly(oligo(ethylene glycol)monomethyl ether methacrylate).

^b1,1’‐dioctadecyl‐3,3,3’,3’‐tetramethindocarbocyanine perchlorate.

^c3,3‐dioctadecyloxacarbocyanine perchlorate.