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. 2017 Jun 1;17(9):1021–1029. doi: 10.1002/elsc.201700039

Figure 1.

Figure 1

Schematic representation of metabolic pathway in the biosynthesis of naringenin via the co‐culture system. The artificial synthetic pathway to naringenin from L‐tyrosine consists of four enzymes encoded by TAL, 4CL, CHS, CHI. Abbreviations: PPP pentose phosphate pathway, PEP phosphoenolpyruvate, E4P erythrose‐4‐phosphate, DAHP 3‐deoxy‐D‐arabino‐heptulosonate‐7‐phosphate, DHS 3‐dehydroshikimic acid, SHK shikimic acid, CHA chorismic acid, 4‐HPP 4‐hydroxyphenylpyruvic acid, L‐Phe L‐phenylalanine, L‐Tyr L‐tyrosine, EPSP 5‐enolpyruvylshikimate‐3‐phosphate, p‐CA p‐coumaric acid, p‐CA‐CoA p‐coumaroyl‐CoA, NC naringenin chalcone, TCA cycle tricarboxylic acid cycle. TAL tyrosine ammonia lyase, 4CL 4‐coumarate‐CoA ligase, CHS chalcone synthase, CHI chalcone isomerase.