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Synthetic pathway for the hydroxylation of tryptophan to 5‐hydroxytryptophan. CtAAAH hydroxylates tryptophan in the presence of oxygen and tetrahydromonapterin. In this reaction the cofactor is oxidated. Afterward, the pterin‐4a‐carbinolamine dehydratase (PCD) dehydrates MH‐4a‐carbinolamine, and dihydropteridine reductase (DHPR) reduces back the pterin cofactor.
