Table 3.
Factors Associated with Use of Inappropriate vs Appropriate Atypical Antipsychotics in Elderly Nursing Home Patients with PD and Comorbid Depression
| Characteristic | Unadjusted OR (%95 OR) | Adjusted OR (%95 OR) |
|---|---|---|
| Age | 1.02 (1.02–1.03) | 1.01 (1.01–1.02) |
| Female vs Male | 1.16 (1.08–1.25) | 1.04 (0.96–1.13) |
| White vs Others | 0.83 (0.74–0.94) | 0.88 (0.77–1.00) |
| College vs Lower education | 0.67 (0.61–0.74) | 0.76 (0.69–0.84) |
| Married vs Unmarried | 0.81 (0.75–0.87) | 0.91 (0.84–0.99) |
| Region | ||
| Midwest | 1.02 (0.94–1.11) | 1.07 (0.98–1.17) |
| Northeast | 0.81 (0.74–0.89) | 0.83 (0.75–0.92) |
| West | 0.97 (0.81–1.16) | 1.11 (0.93–1.34) |
| South | Ref | Ref |
| ADL Score | 1.00 (0.99–1.00) | 1.00 (0.99–1.00) |
| MDS Cognitive Score | 0.98 (0.96–1.01) | 0.98 (0.95–1.02) |
| Impaired Walking (Yes vs No) | 0.93 (0.86–0.99) | 1.00 (0.93–1.08) |
| Unclear Speech (Yes vs No) | 1.00 (0.91–1.10) | 1.07 (0.96–1.18) |
| Dyskinesia, n (%) | 0.76 (0.58–0.99) | 0.96 (0.73–1.26) |
| Dysphagia, n (%) | 0.91 (0.85–0.98) | 0.93 (0.86–1.00) |
| Abusive Behavior (Yes vs No) | 1.10 (0.98–1.22) | 1.12 (0.99–1.25) |
| Insomnia (Yes vs No) | 0.88 (0.79–0.98) | 0.90 (0.80–1.00) |
| Depressed Mood Indicators (Present vs Absent) | 0.94 (0.87–1.01) | 0.93 (0.86–1.01) |
| Depressive Type Psychosis (Yes vs No) | 1.06 (0.73–1.56) | 1.06 (0.72–1.56) |
| Anxiety (Yes vs No) | 1.13 (1.05–1.21) | 1.08 (1.00–1.17) |
| Dementia (Yes vs No) | 1.40 (1.29–1.51) | 1.22 (1.12–1.33) |
| Stroke (Yes vs No) | 1.19 (1.10–1.30) | 1.09 (1.00–1.19) |
| Falls and Fractures (Yes vs No) | 0.95 (0.86–1.05) | 0.92 (0.83–1.02) |
| Coronary Artery Disease (Yes vs No) | 1.13 (1.04–1.23) | 1.04 (0.95–1.14) |
| Congestive Heart Failure (Yes vs No) | 1.19 (1.10–1.29) | 1.02 (0.93–1.11) |
| Dysrhythmia (Yes vs No) | 1.08 (0.99–1.18) | 1.00 (0.91–1.09) |
| Hypertension (Yes vs No) | 1.22 (1.12–1.33) | 1.05 (0.96–1.15) |
| Diabetes Mellitus (Yes vs No) | 1.18 (1.09–1.27) | 1.06 (0.98–1.15) |
| Osteoarthritis (Yes vs No) | 1.12 (1.04–1.20) | 1.02 (0.94–1.10) |
| Cancer (Yes vs No) | 0.91 (0.81–1.02) | 0.88 (0.78–0.99) |
| Pneumonia history (Yes vs No) | 1.01 (1.01–1.17) | 1.01 (0.93–1.10) |
| Asthma (Yes vs No) | 1.11 (0.94–1.30) | 1.00 (0.84–1.18) |
| COPD (Yes vs No) | 1.24 (1.14–1.35) | 1.13 (1.03–1.24) |
| Charlson Comorbidity Index | 1.02 (1.01–1.03) | 1.01 (1.00–1.02) |
| Typical antipsychotics, n (%) | 1.23 (1.08–1.41) | 1.09 (0.95–1.25) |
| SSRI/SNRI (Used vs Not Used) | 1.09 (1.01–1.18) | 1.14 (1.06–1.24) |
| Levodopa (Used vs Not Used) | 0.55 (0.51–0.59) | 0.62 (0.57–0.67) |
| Dopamine Agonists (Used vs Not Used) | 0.74 (0.68–0.80) | 0.90 (0.82–0.98) |
| COMT Inhibitors (Used vs Not Used) | 0.53 (0.48–0.59) | 0.77 (0.68–0.86) |
| MAO Inhibitors Type B (Used vs Not Used) | 0.50 (0.42–0.59) | 0.72 (0.60–0.86) |
| Amantadine (Used vs Not Used) | 0.64 (0.55–0.75) | 0.84 (0.71–0.98) |
| Anticholinergics (Used vs Not Used) | 1.00 (0.85–1.18) | 1.08 (0.91–1.28) |