Table 2.
Bioactivity of neat and RosA‐loaded CA nanofibers as well as extracts from nanofibers
| Formulation | Inhibition of protein denaturation (%) | Antioxidant activity (%) |
|---|---|---|
| Ibuprofene dissolved in acetone (200 μg/mL) | 50 ± 4♯ | ‐ |
| RosA released from CA/5% RosA in acetone (74 ± 10 μg/mL)a | 32 ± 3♯,‡ | ‐ |
| RosA released from CA/10% RosA in acetone (140 ± 6 μg/mL)a | 49 ± 4‡ | ‐ |
| RosA released from CA/5% RosA in acetone (22 ± 3 μg/mL)b | ‐ | 35 ± 1٭ |
| RosA released from CA/10% RosA in acetone (42 ± 2 μg/mL)b | ‐ | 79 ± 2٭ |
| RosA released from CA/5% RosA in buffer after 4 h (31 ± 1 μg/mL)c | 9 ± 2ǂ,† | 12.0 ± 1ǂ,† |
| RosA released from CA/10% RosA in buffer after 4 h (55 ± 6 μg/mL)c | 18 ± 3ǂ,§ | 34.0 ± 1ǂ,§ |
| RosA released from CA/5% RosA in buffer after 25 h (72 ± 1 μg/mL)c | 20 ± 2ǂǂ,† | 41 ± 1ǂǂ,† |
| RosA released from CA/10% RosA in buffer after 25 h (139 ± 21 μg/mL)c | 43 ± 3ǂǂ,§ | 82 ± 1ǂǂ,§ |
a
RosA released from 5 mg nanofibers dissolved in 3 mL of acetone.
b
RosA released from 5 mg nanofibers dissolved in 10 mL of acetone.
c
RosA released from 5 mg nanofibers in 2 mL of sodium acetate buffer solution.
Bioactivity of neat CA and its extracts were negligible. ♯, ‡ ٭,ǂ, ǂǂ,†,§ indicate significant differences between corresponding values at p < 0.05.