Table 4.

Binding energies between substrates and enzymes (FPPS, ECS, and FPPS‐ECS fusion)

	Substrates	FPPS	ECS	FPPS‐ECS fusion
1.	IPP	−5.6	–	−6.2 kcal/mol
2.	DMAPP	−5.6	–	−6.2 kcal/mol
3.	FPP	–	−7.0	−7.2 kcal/mol

ECS, epi‐cedrol synthase; FPPS, farnesyl pyrophosphate synthase.