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. 2019 Jun 24;16(3):512–530. doi: 10.1080/15548627.2019.1630222

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 8. — SGK3 is critical for CORT-induced cell death, but dispensable for apoptosis or necroptosis in HCN cells. (A and B) Changes in the expression levels of SGK1, 2, and 3 following CORT treatment in HCN cells. mRNA levels after CORT treatment for 24 h (n = 3) (A). Western blotting analyses of protein levels (B). Blots are representative of 3 experiments with similar results. (C) KO of Sgk1 (sgSgk1) and Sgk2 (sgSgk2). (D) Death rates of sgSgk1 and sgSgk2 cells after CORT treatment for 48 h (n = 3). (E) KO of Sgk3 (sgSgk3). (F) Death rate of sgSgk3 cells (n = 8). (G) Death rate of sgSgk3 cells after STS treatment (0.5 μM) for 24 h (n = 3). (G) Death rate of sgSgk3 cells after H₂O₂ treatment (100 μM) for 6 h (n = 3). ***P < 0.001. n.s., not significant.