Table 3.
Demographic Characteristics, Potential Risk Factors, and Disease Patterns in Reported Cases of Neonates with Zygomycosis
| Characteristic | All Patients Reported, n (%) | Reported Patients Who Died, n (%) |
|---|---|---|
| Patients | 59 (100) | 38 (64) |
| Demographics | ||
| Male gender | 33 (57) | 22 (67) |
| Female gender | 25 (43) | 16 (64) |
| GA in wk, median (IQR) | 28 (25–39) | 28 (25–34) |
| BW in g, median (IQR) | 1131 (745–1895) | 1131 (730–1710) |
| Postnatal age in d, median (IQR) | 12 (8–18) | 11.5 ± 1.3 (2–22) |
| Potential risk factors for death | ||
| Prematurity (<38 wk) | 37/48 (77) | 20/37 (54) |
| Corticosteroids | 18/34 (53) | 8/18 (44) |
| Antibiotics | 41/53 (77) | 25/41 (61) |
| Major surgery prior to the infection | 12/57 (21) | 8/12 (67) |
| Impaired host defense* | 3 | 2/3 (67) |
| Metabolic acidosis | 7 | 6/7 (86) |
| Contaminated source† | 20 | 10/20 (50) |
| Hyperglycemia | 5 | 3/5 (60) |
| Disease pattern | ||
| GI tract | 32 (54) | 25/32 (78) |
| Cutaneous | 21 (36) | 8/21 (38) |
| Pulmonary‡ | 4 (7) | 4/4 (100) |
| Rhino-orbital-cerebral | 2 (3) | 1/2 (50) |
| Extension of disease | ||
| Localized | 21 (36) | 10/21 (48) |
| Deeply extensive | 5 (8) | 1/5 (20) |
| Disseminated | 33 (56) | 28/33 (85) |
*
Other than corticosteroid treatment.
†
Wooden tongue depressors, intravenous catheter sites, etc.
‡
One case with concomitant cutaneous infection; one case disseminated to multiple organs.
GA, gestationalage; BW, body weight, IQR, interquartile range; GI, gastrointestinal.