Storr 1987.
Methods | setting: children's hospital, Brighton, England design: randomised double‐blind controlled trial, parallel design length of intervention: 36 hours masking: double‐blind excluded: stated withdrawals: stated baseline characteristics: similar in both treatment groups | |
Participants | 140 children mean age: 5.3 y: M 97, F 43 prednisone arm: n=67 control arm: n=73 inclusion criteria: children hospitalised with moderate or severe asthma exclusion criteria: Other lung illnesses such as croup, pneumonia, pertussis. Vomited drink or previous "steroids" in the most recent 48h | |
Interventions | Oral prednisolone3mg/kg prednisolone in water (one dose)
(children<5y got 30mg and others got 60mg)
OR
grapefruit juice all children got standard therapy of nebulised salbutamol 5mg in 2 ml saline on admission and >3 times daily as needed |
|
Outcomes | Discharge at first re‐examination (4h) % expected PEFR (6h) Requirement for suplimentary therapy |
|
Notes | Jadad score 5 | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | A ‐ Adequate |