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Sphingolipid metabolism and interconnected bioactive sphingolipid metabolites. The various enzymes that mediate interconversion between various bioactive lipids are localized with the lipids themselves. Ceramide is produced from sphingomyelin by SMase. Ceramide can be hydrolyzed to sphingosine, which is then phosphorylated to sphingosine-1-phosphate (S1P) by sphingosine kinase (SphK).
