Figure 1.
Sequences of integrin-α11/β1 Abs. Abs were isolated by screening a phage-displayed Fab library for binding to (a) purified integrin-α11/β1 or (b) integrin-α11/β1 displayed on live cells. Sequences are shown for positions that were diversifed in the library and are numbered according to the IMGT nomenclature.39 Dashes indicate gaps in the alignment. Underlined bold text indicates Abs that inhibited integrin-α11/β1 binding to collagen-1, and asterisks (*) indicate Abs that were also characterized as full-length immunoglobulins.